PLx Pharma Inc. Presents Original Abstract and Simultaneous Publication of its Novel, Liquid-Filled Capsule Aspirin Formulation at the 2020 International Stroke Conference
Abstract Title: Bioavailability of Aspirin in Fasted and Fed States of a Novel Formulation of a
In this randomized, open label, crossover study, 20 healthy volunteers fasted for at least ten hours and were then randomized as either “fasted,” receiving 650 mg of PL-ASA, or as “fed,” with a standard high-fat meal and 650 mg of PL-ASA 30 minutes later. After a washout of seven days, participants crossed over to the other arm. The primary outcome was comparison of pharmacokinetic (PK) parameters of the stable aspirin metabolite salicylic acid (SA) between fasted and fed states. The results established that PL-ASA may be co-administered with food without significant impact on aspirin bioavailability.
“The data presented at the
“Aspirin continues to be the cornerstone of lifelong antithrombotic protection for patients with established atherosclerotic cardiovascular disease. The data presented here, and now published, complement previous studies with this lipid-based formulation of aspirin. It is encouraging that a new formulation of aspirin combining both reliable absorption and antiplatelet effect with improved gastrointestinal safety may soon be available for our patients,” added
“VAZALORE continues to deliver outstanding results that address important unmet clinical needs of the currently available aspirin formulations. We believe that VAZALORE has the potential to address the long-standing need for a new, better aspirin product, and we will continue our efforts to make VAZALORE available to the millions of high-risk cardiovascular patients who require reliable lifelong vascular protection,” concluded Efthymios N. Deliargyris, MD,
VAZALORE 325 mg is an
To learn more about
Any statements made in this press release relating to future financial or business performance, conditions, plans, prospects, trends, or strategies and other financial and business matters, including without limitation, the prospects for commercializing or selling any products or drug candidates, are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. In addition, when or if used in this press release, the words “may,” “could,” “should,” “anticipate,” “believe,” “estimate,” “expect,” “intend,” “plan,” “predict” and similar expressions and their variants, as they relate to PLx may identify forward-looking statements. PLx cautions that these forward-looking statements are subject to numerous assumptions, risks, and uncertainties, which change over time. Important factors that may cause actual results to differ materially from the results discussed in the forward-looking statements or historical experience include risks and uncertainties, including the failure by PLx to secure and maintain relationships with collaborators; risks relating to clinical trials; risks relating to the commercialization, if any, of PLx’s proposed product candidates (such as marketing, regulatory, product liability, supply, competition, and other risks); dependence on the efforts of third parties; dependence on intellectual property and risks that PLx may lack the financial resources and access to capital to fund proposed operations. Further information on the factors and risks that could affect PLx’s business, financial conditions and results of operations are contained in PLx’s filings with the U.S. Securities and Exchange Commission (
In-Site Communications, Inc.
Source: PLx Pharma Inc.